Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections
نویسندگان
چکیده
Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunologic evaluation for anti-GM-CSF antibodies may be important to inform management and counseling.
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(9). Although these autoantibodies have not been reported in patients with Listeria infections, susceptibility to infection caused by this bacterium is increased in GM–colony-stimulating factor –/– mice (10). Autoantibodies against GM–colony-stimulating factor or perhaps other cytokines might have impaired the patient's host defense against these organisms; unfortunately, our report is limited ...
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